RNAzol RNA Isolation Reagent 产品说明书

MaterialSafetyDataSheet

RevisionDate:February23,2018

FICATIONOFTHESUBSTRANCE/PREPARATIONANDTHE

COMPANY/UNDERTAKING

Productcode

Productname

Contactmanufacturer

GeneCopoeia,Inc.

9620MedicalCenterDrive,Suite101

Rockville,MD20850

USA

Phone:301-762-0888

Tollfree:1-866-360-9531

Fax:301-762-3888

QP020

RNAzol®RTRNAIsolationReagent

ITION/INFORMATIONONINGREDIENTS

ChemicalName

Phenol

Guanidineisothiocyanate

Ammoniumthiocyanate

CAS-No

108-95-2

593-84-0

1762-95-4

Weight%

30-60

15-40

7-13

DDacidsorbleachtoanyliquidwastescontaining

mmendhandlingallchemicalswithcaution.

SIDENTIFICATION

GHS–Classification

SignalWord

DANGER

HealthHazards

Acuteoraltoxicity

Acutedermaltoxicity

AcuteInhalationToxicity-Vapors

Skincorrosion/irritation

Seriouseyedamage/eyeirritation

Specifictargetorgansystemictoxicity(singleexposure)

Specifictargetorgansystemictoxicity(repeatedexposure)

Category4

Category4

Category4

Category1B

Category1

Category3

Category3

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HealthHazards(continued)

Mutagenicity

Physicalhazards

Nothazardous

HazardStatements

H314-Causessevereskinburnsandeyedamage

H341-Suspectedofcausinggeneticdefects

H373-Maycausedamagetoorgansthroughprolongedorrepeatedexposure

H412-Harmfultoaquaticlifewithlonglastingeffects

H302-Harmfulifswallowed

H312-Harmfulincontactwithskin

H332-Harmfulifinhaled

H335-Maycauserespiratoryirritation

PrecautionaryStatements

P301+P312-IFSWALLOWED:CallaPOISONCENTERordoctor/physicianifyoufeelunwell

P304+P340-IFINHALED:Removevictimtofreshairandkeepatrestinapositioncomfortableforbreathing

P301+P330+P331-IFSWALLOWED:nducevomiting

P303+P361+P353-IFONSKIN(orhair):Remove/kin

with

water/shower

P305+P351+P338-IFINEYES:contactlenses,if

uerinsing

P310-ImmediatelycallaPOISONCENTERordoctor/physician

P308+P313-IFexposedorconcerned:Getmedicaladvice/attention

P273-Avoidreleasetotheenvironment

P280-Wearprotectivegloves/protectiveclothing/eyeprotection/faceprotection

PrincipleRoutesofExposure

PotentialHealthEffects

Eyes

Skin

Inhalation

Ingestion

ivetotheeyes

andmaycauseseveredamageincludingblindness.

lincontact

withskin.

Irritatingtoskinandmucousmembranes.

Harmfulbyinhalation.

ioncausesburnsoftheupperdigestiveand

ionmaycausegastrointestinalirritation,nausea,

vomitinganddiarrhea.

PhenolhasbeenclassifiedbytheInternationalAgencyforResearchon

Cancer(IARC)asnotclassifiableastocarcinogenicitytohumans

(Group3).

NotApplicable

NotApplicable

NotApplicable

Skin

Lungs

Liver

Spleen

Mutageniccategory2

Specificeffects

Carcinogeniceffects

Mutageniceffects

Reproductivetoxicity

Sensitization

TargetOrganEffects

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Kidney

HMIS

Health

Flammability

Reactivity

IDMEASURES

Skincontact

Eyecontact

3*ChronicHazard

1

0

Ingestion

Inhalation

Notestophysician

Washoffimmediatelywithsoapandplentyofwaterwhileremovingall

hysicianimmediately.

IFINEYES:

contactlenses,

immediatelywithplentyofwater,alsoundertheeyelids,foratleast15

hysicianimmediately.

iveanythingby

mouthtoanunconsciousperson.

hysicianorpoisoncontrolcenter

immediately.

Treatsymptomatically.

-FIGHTINGMEASURES

Suitableextinguishingmedia

Specialprotectiveequipment

forfirefighters

AustraliaHazChemCode

dioxide(CO2)..

Wearself-containedbreathingapparatusandprotectivesuit.

2X

NTALRELEASEMEASURES

PersonalprecautionsELIMINATEallignitionsources(nosmoking,flares,sparksorflamesin

immediatearea).ontactwith

skin,opleaway

fromandupwindofspill/tepersonneltosafeareas.

withinertabsorbent

lizespillwithslakedlime,sodiumbicarbonateorcrushed

tpowderedmaterialanddepositinsealedcontainers

eareaanddenyentry.

Methodsforcleaningup

Environmentalprecautions

tproductfrom

llowmaterialtocontaminategroundwater

system.

SeeSection12formoreinformation

NGANDSTORAGE

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Handling

Storage

contactwithskin,allsourcesofignition.

Keepcontainerstightlyclosedinacool,ay

fromheat,sparks,,pilotlights,

electricmotorsandstaticelectricity).Protectfromsunlight.

RECONTROLS/PERSONALPROTECTION

Exposurelimits

Chemicalname

Phenol

Guanidineisothiocyanate

Ammoniumthiocyanate

Engineeringmeasures

Personalprotectiveequipment

OSHAPEL

5ppm19mg/m

3

None

5mg/m

3

OSHAPEL(Ceiling)

None

None

None

ACGIHOEL(TWA)

5ppm

None

None

ACGIHOEL(STEL)

None

None

None

Useinachemicalfumehood

PersonalProtectiveEquipmentrequirementsaredependentontheuser

institution'sriskassessmentandarespecifictotheriskassessmentfor

eachlaboratorywherethismaterialmaybeused.

Incaseofinsufficientventilationwearsuitablerespiratoryequipment

Upto50ppm

(APF=10)Anyair-purifyinghalf-maskrespiratorwithorganicvapor

cartridge(s)incombinationwithanN95,R95,lowing

filtersmayalsobeused:

N99,R99,P99,N100,R100,P100.

(APF=10)Anysupplied-airrespirator

Upto125ppm:

(APF=25)Anysupplied-airrespiratoroperatedinacontinuous-flow

mode.

(APF=25)Anypoweredair-purifyingrespiratorwithanorganicvapor

cartridgeincombinationwithahigh-efficiencyparticulatefilter.

Upto250ppm:

(APF=50)Anyair-purifyingfull-facepiecerespiratorequippedwith

organicvaporcartridge(s)incombinationwithanN100,R100,orP100

filter.

(APF=50)Anyair-purifying,full-facepiecerespirator(gasmask)witha

chin-style,front-orback-mountedorganicvaporcanisterhavingan

N100,R100,orP100filter.

(APF=50)Anypowered,air-purifyingrespiratorwithatight-fitting

facepieceandorganicvaporcartridge(s)incombinationwithahigh-

efficiencyparticulatefilter.

(APF=50)Anyself-containedbreathingapparatuswithafullfacepiece.

(APF=50)Anysupplied-airrespiratorwithafullfacepiece.

EmergencyorplannedentryintounknownconcentrationsorIDLH

conditions:

(APF=10,000)Anyself-containedbreathingapparatusthathasafull

facepieceandisoperatedinapressure-demandorotherpositive-

pressuremode.

Respiratoryprotection

Respirator

Recommendations,National

InstituteofOccupational

SafetyandHealth,U.S.

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Handprotection

Eyeprotection

Skinandbodyprotection

Hygienemeasures

(APF=10,000)Anysupplied-airrespiratorthathasafullfacepieceand

isoperatedinapressure-demandorotherpositive-pressuremodein

combinationwithanauxiliaryself-containedpositive-pressurebreathing

apparatus.

Escape:

(APF=50)Anyair-purifying,full-facepiecerespirator(gasmask)witha

chin-style,

front-orback-mountedorganicvaporcanisterhavinganN100,R100,or

P100filter./Anyappropriateescape-type,self-containedbreathing

apparatus.

Imperviousgloves.S24-Avoidcontactwithskin.S36-Wearsuitable

protectiveclothing.

Tightsealingsafetygoggles.

Imperviousclothing.

Contaminatedworkclothingshouldnotbeallowedoutoftheworkplace.

Avoidcontactwithskin,inaccordancewith

goodindustrialhygieneandsafetypractice.

Preventproductfromenteringdrains.

Environmentalexposure

Controls

ALANDCHEMICALPROPERTIES

Generalinformation

Form

Appearance

Odor

Boilingpoint/range

Meltingpoint/range

Flashpoint

Autoignitiontemperature

Oxidizingproperties

Watersolubility

Liquid.

Red,maroon.

Medicinal,sweet,tar-like.

°CNodataavailable

°CNodataavailable

°CNodataavailable

°CNodataavailable

Noinformationavailable

Soluble

°FNodataavailable

°FNodataavailable

°FNodataavailable

°FNodataavailable

ITYANDREACTIVITY

Stability

Materialstoavoid

Hazardousdecomposition

Products

Polymerization

Stableundernormalconditions.

es,

oxidizers,alkalimetalsand

alkalineearthmetalsmaycausefiresorexplosions.

encyanide(hydrocyanicacid).Carbon

oxides,

NitrogenOxides.

Hazardouspolymerizationdoesnotoccur.

LOGICALINFORMATION

Acutetoxicity

Chemicalname

Phenol

Guanidineisothiocyanate

LD50(oral,rat/mouse)

=317mg/kg(Rat)

571mg/kg

LD50(dermal,rat/rabbit)

Nodataavailable

2000mg/kg

LC50(inhalation,rat/mouse)

=316mg/m3(Rat)

5.319mg/L(4H)

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Ammoniumthiocyanate=500mg/kg(Rat)NodataavailableNodataavailable

PrincipleRoutesofExposure

PotentialHealthEffects

Eyes

Skin

Inhalation

Ingestion

Carcinogeniceffects

Mutageniceffects

Reproductivetoxicity

Sensitization

Targetorganeffects

seriousdamagetoeyesCorrosivetotheeyesand

maycauseseveredamageincludingblindness.

leriskofirreversibleeffectsHarmfulincontactwith

tingtoskinandmucousmembranes.

Harmfulbyinhalation

HarmfulifswallowedIngestioncausesburnsoftheupperdigestiveand

respiratorytractsIngestionmaycausegastrointestinalirritation,nausea,

vomitinganddiarrhea

PhenolhasbeenclassifiedbytheInternationalAgencyforResearchon

Cancer(IARC)asnotclassifiableastocarcinogenicitytohumans

(Group3).

Noinformationavailable.

Noinformationavailable.

Noinformationavailable.

Skin.

Lungs.

Liver.

Spleen.

Kidney.

ICALINFORMATION

Ecotoxicity

Chronicaquatictoxicity

Mobility

Biodegradation

Bioaccumulation

Chemicalname

Phenol

Harmfultoaquaticorganisms,maycauselong-termadverseeffectsin

theaquaticenvironment.

Category3

SeelogPow

Inherentlybiodegradable

Noinformationavailable

Waterfleadata

Daphniamagna

EC50

4.24-10.7mg/L

(48

h)Daphnia

magna

EC5010.2-

15.5mg/L

(48h)

Freshwaterfishspecies

data

=316mg/m3(Rat)

Microtox

data

LogPow

logPow1.

47

Freshwateralgaedata

Desmodesmus

subspicatusEC50187

-279mg/L(72h)

Pseudokirchneriella

subcapitataEC50

46.42mg/L(96h)

ALCONSIDERATIONS

Disposeofcontents/containersinaccordancewithlocalregulations.

ORTINFORMATION

IATA

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Propershippingname

HazardClass

Subsidiaryclass

Packinggroup

UN-No

ERGCode

s.(guanidinethiocyanate-phenolsolution).

8

None

II

1760

153

TARYINFORMATION

Component

Phenol,108-95-2(30-60)

Guanidineisothiocyanate,593-84-0(15-40)

Ammoniumthiocyanate1762-95-4(7-13)

USFederalRegulations

SARA313

Thisproductcontainsthefollowingtoxicchemical(s)subjecttothenotificationrequirementsofsection313ofTitle

wrequirescertainmanufacturersto

rnotethatifyourepackage,or

otherwiseredistribute,thisproducttoindustrialcustomers,anoticesimilartothisoneshouldbesenttothose

customers:

Chemicalname

Phenol

Ammoniumthiocyanate

CAS-No.

108-95-2

1762-95-4

Weight%

30-60

7-13

SARA313-Thresholdvalues

1.0

1.0

TSCA

Listed

Listed

Listed

CleanAirAct,Section112HazardousAirPollutants(HAPs)(see40CFR61)

ThisproductcontainsthefollowingHAPs:

Component

Phenol

Ammoniumthiocyanate

CAS-No.

108-95-2

1762-95-4

Weight%

30-60

7-13

HAPSdata

Present

Present(XCNwhereX=Horany

othergroupwhereaformal

exampleKCNorCa[CN]2)

USstateregulations

Chemicalname

Phenol

Guanidineisothiocyanate

Ammoniumthiocyanate

Massachusetts

-RTK

Listed

-

Listed

NewJersey-

RTK

Listed

-

-

Pennsylvania-

RTK

Listed

-

Listed

Illinois-RTK

Listed

-

Listed

RhodeIsland-

RTK

Listed

-

Listed

CaliforniaProposition65

ThisproductdoesnotcontainanyProposition65chemicals.

WHMISHazardClass

D1A-Verytoxicmaterials

E-Corrosivematerial

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of8

ThisproducthasbeenclassifiedinaccordancewiththehazardcriteriaoftheControlledProductsRegulations

(CPR)andtheMSDScontainsalltheinformationrequiredbytheCPR.

NFORMATION

Reasonforrevision

Forresearchuseonly.

"Theaboveinformationwasacquiredbydiligentsearchand/orinvestigationandtherecommendationsarebased

ormationshallnotbetakenasbeingallinclusiveandisto

erialsandmixturesmaypresentunknownhazardsandshouldbeusedwith

heCompanycannotcontroltheactualmethods,volumes,orconditionsofuse,theCompanyshall

notbeheldliableforanydamagesorlossesresultingfromthehandlingorfromcontactwiththeproductas

describedherein.

THEINFORMATIONINTHISSDSDOESNOTCONSTITUTEAWARRENTY,EXPRESSEDORIMPLIED,

INCLUDINGANYIMPLIEDWARRANTYOFMERCHANTABILITYORFITNESSFORANYPARTICULAR

PUPOSE"

tionsupdated.

EndofSafetyDataSheet

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